Physical examination maneuver

Physical Exam

Cardiac Auscultation

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Video coming September 2026

How to Perform

With the patient supine or seated in a quiet room, listen directly on the skin in the second intercostal space at the right sternal border, the second intercostal space at the left sternal border, the lower left sternal border at the fourth or fifth intercostal space, and the fifth intercostal space at the left midclavicular line. At each site, listen with light pressure using a tunable diaphragm (or a lightly applied bell) for lower-pitched sounds, then press the tunable diaphragm more firmly for higher-pitched sounds. Identify S1 and S2 and listen through systole and diastole for murmurs or added sounds. If a murmur is loud, place the finger pads directly on the skin over the site where the murmur is loudest and palpate for a thrill. Use the presence or absence of a thrill as part of grading the murmur.

How to Interpret

Showing 35 of 91 findings

Acute Aortic Dissection

Diastolic murmur of aortic regurgitation
Rule in
Minimally helpful
Rule out
Not helpful
Evidence:Strong

Aortic Regurgitation

Decrescendo diastolic murmur at left sternal border
Rule in
Helpful
Rule out
Somewhat helpful
Evidence:Limited

Aortic Stenosis

Systolic murmur
Rule in
Somewhat helpful
Rule out
Very helpfulDerived CI
Evidence:Limited
Broad apical murmur pattern
Rule in
Rule out
Helpful
Evidence:Limited
S1 inaudible
Rule in
Helpful
Rule out
Evidence:Limited
Coarse quality murmur
Rule in
Somewhat helpful
Rule out
Evidence:Limited
Murmur same intensity in beat after pause
Rule in
Rule out
Somewhat helpful
Evidence:Limited
Left lower sternal border murmur pattern
Rule in
Rule out
InconclusiveWide CI
Evidence:Limited
S2 loud
Rule in
InconclusiveWide CI
Rule out
Evidence:Limited
Diminished or absent A2 (soft second heart sound) on auscultation
Rule in
Very helpful
Rule out
Somewhat helpful
Evidence:Strong
Mid-to-late peaking systolic murmur (peak past mid-systole)
Rule in
Very helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Limited
Systolic murmur radiating to the carotids
Rule in
Somewhat helpful
Rule out
Helpful
Evidence:Strong
S4 gallop
Rule in
Somewhat helpful
Rule out
Somewhat helpful
Evidence:Limited
Blowing murmur quality
Rule in
Rule out
Very helpfulNo CI
Evidence:Limited
Early-systolic murmur timing
Rule in
Rule out
Very helpfulNo CI
Evidence:Limited
Prolonged murmur duration
Rule in
Somewhat helpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Limited
Gallavardin phenomenon (musical, high-pitched component of the aortic stenosis murmur at the apex, mimicking mitral regurgitation)
Rule in
Somewhat helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Limited
Murmur grade 3 or louder
Rule in
Not helpfulDerived CI
Rule out
InconclusiveWide CI
Evidence:Limited

Functional Systolic Murmur

Systolic murmur judged functional/innocent on bedside auscultation
Rule in
HelpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Limited

Heart Failure

S3 gallop
Rule in
Very helpful
Rule out
Not helpful
Evidence:Strong

Hypertrophic Cardiomyopathy

Systolic murmur louder on standing up from a squat
Rule in
HelpfulNo CI
Rule out
Very helpfulNo CI
Evidence:LimitedResearch in progress
Systolic murmur softer on squatting from standing
Rule in
HelpfulNo CI
Rule out
Very helpfulNo CI
Evidence:LimitedResearch in progress
Systolic murmur that increases with the Valsalva maneuver
Rule in
Very helpfulNo CI
Rule out
Somewhat helpfulNo CI
Evidence:LimitedResearch in progress
Systolic murmur softens with passive leg elevation
Rule in
HelpfulNo CI
Rule out
HelpfulNo CI
Evidence:LimitedResearch in progress
Systolic murmur that decreases with isometric handgrip
Rule in
Somewhat helpfulNo CI
Rule out
HelpfulNo CI
Evidence:LimitedResearch in progress

Mitral Regurgitation

Systolic murmur louder with isometric handgrip
Rule in
HelpfulNo CI
Rule out
Somewhat helpfulNo CI
Evidence:LimitedResearch in progress
Systolic murmur unchanged in intensity in the beat after a pause (irregular pulse)
Rule in
Somewhat helpful
Rule out
Evidence:Limited
Broad apical-base murmur pattern
Rule in
Not helpful
Rule out
Not helpful
Evidence:Limited
Systolic murmur
Rule in
Not helpful
Rule out
Not helpfulDerived CI
Evidence:Limited

Mitral Valve Prolapse

Mid-systolic click
Rule in
Minimally helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Limited

Myocardial Infarction

Third heart sound
Rule in
Somewhat helpfulDerived CI
Rule out
Evidence:Limited

Pulmonary Embolism

Loud P2
Rule in
Somewhat helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:Limited

Pulmonary Hypertension

Loud P2
Rule in
InconclusiveWide CI
Rule out
Minimally helpful
Evidence:Limited

Right-sided Valvular Lesion

Carvallo sign (systolic murmur intensity increases with inspiration)
Rule in
HelpfulDerived CI
Rule out
Very helpfulDerived CI
Evidence:Limited

Tricuspid Regurgitation

Broad apical-base murmur pattern
Rule in
Not helpfulWide CI
Rule out
Not helpfulWide CI
Evidence:Limited

References

Research in progress on one or more findings above; ratings may change.

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  • McGee SR. Etiology and diagnosis of systolic murmurs in adults. Am J Med. 2010;123(10):913-921. PMID: 20920693.
  • Lembo NJ, Dell'Italia LJ, Crawford MH, O'Rourke RA. Bedside diagnosis of systolic murmurs. N Engl J Med. 1988;318(24):1572-1578. PMID: 2897627.
  • Davidsen AH, Andersen S, Halvorsen PA, Aviles Solis JC, Schirmer H, Melbye H. Heart murmurs in the general population: diagnostic value and prevalence from the Tromsø Study. Heart. 2025;112(2):103-110. doi:10.1136/heartjnl-2024-325499. PMID 40750340. PMC12772608.
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  • Shellenberger RA, Imtiaz K, Chellappa N, Gundapanneni L, Scheidel C, Handa R, Bhat A. Physical Examination for the Detection of Pulmonary Hypertension: A Systematic Review. Cureus. 2021 Sep 16;13(9):e18020. doi:10.7759/cureus.18020. PMID: 34692270. PMCID: PMC8523183.
  • Cohn KE, Hultgren HN. The Graham Steell murmur re-evaluated. N Engl J Med. 1966;274(9):486-489. PMID: 4221906.
  • McGee S. Etiology and diagnosis of systolic murmurs in adults. Am J Med. 2010;123(10):913-921. PMID: 20920693.
  • Gamaza-Chulián S, Serrano-Muñoz B, Díaz-Retamino E, et al. Physical examination in aortic stenosis. Correlation with echocardiographic and peripheral Doppler echocardiography findings. REC CardioClinics. 2020;55(2):139-146.
  • Closest candidate: Gamaza-Chulián S, Serrano-Muñoz B, Díaz-Retamino E, et al. Physical examination in aortic stenosis. Correlation with echocardiographic and peripheral Doppler echocardiography findings. REC CardioClinics. 2020;55(2):139-146. (Not indexed in PubMed; no PMID.)
  • Aronow WS, Kronzon I. Correlation of prevalence and severity of valvular aortic stenosis determined by continuous-wave Doppler echocardiography with physical signs of aortic stenosis in patients aged 62 to 100 years with aortic systolic ejection murmurs. Am J Cardiol. 1987;60(4):399-401. PMID: 3497570
  • Shellenberger RA, Crass S, Jevicks J, Badhwar A, Albright J, Kumar A. Bedside Physical Examination for the Diagnosis of Aortic Stenosis: A Systematic Review and Meta-analysis. CJC Open. 2023 Feb 27;5(5):373-379. doi:10.1016/j.cjco.2023.02.007. PMID 37377515. PMC10290951.
  • Etchells E, Bell C, Robb K. Does this patient have an abnormal systolic murmur? JAMA. 1997;277(7):564-571. PMID: 9032164.
  • McGee S. Etiology and diagnosis of systolic murmurs in adults. Am J Med. 2010;123(10):913-921.e1. PMID: 20920693.
  • Etchells E, Glenns V, Shadowitz S, Bell C, Siu S. A bedside clinical prediction rule for detecting moderate or severe aortic stenosis. J Gen Intern Med. 1998;13(10):699-704. PMID: 9798818. PMC1500900.
  • Lembo NJ, Dell'Italia LJ, Crawford MH, O'Rourke RA. Bedside diagnosis of systolic murmurs. N Engl J Med. 1988;318(24):1572-8. PMID: 2897627.
  • Lembo NJ, Dell'Italia LJ, Crawford MH, O'Rourke RA. Bedside diagnosis of systolic murmurs. N Engl J Med. 1988;318(24):1572-1578. PMID: 2897627. doi:10.1056/NEJM198806163182404.
  • Lembo NJ, Dell'Italia LJ, Crawford MH, O'Rourke RA. Bedside diagnosis of systolic murmurs. N Engl J Med. 1988;318(24):1572-1578. doi:10.1056/NEJM198806163182404. PMID: 2897627.
  • Wang CS, FitzGerald JM, Schulzer M, Mak E, Ayas NT. Does this dyspneic patient in the emergency department have congestive heart failure? JAMA. 2005 Oct 19;294(15):1944-1956. doi:10.1001/jama.294.15.1944. PMID 16234501.
  • Choudhry NK, Etchells EE. The rational clinical examination. Does this patient have aortic regurgitation? JAMA. 1999 Jun 16;281(23):2231-2238. doi:10.1001/jama.281.23.2231. PMID: 10376577.
  • Harvey WP, Corrado MA, Perloff JK. "Right-sided" murmurs of aortic insufficiency (diastolic murmurs better heard to the right of the sternum rather than to the left). Am J Med Sci. 1963;245:533-543. PMID: 13960803.
  • Desjardins VA, Enriquez-Sarano M, Tajik AJ, Bailey KR, Seward JB. Intensity of murmurs correlates with severity of valvular regurgitation. Am J Med. 1996;100(2):149-156. PMID: 8629648.
  • Panju AA, Hemmelgarn BR, Guyatt GH, Simel DL. The Rational Clinical Examination. Is this patient having a myocardial infarction? JAMA. 1998;280(14):1256-1263. PMID: 9786377.
  • Spodick DH. Pericardial rub. Prospective, multiple observer investigation of pericardial friction in 100 patients. Am J Cardiol. 1975;35(3):357-362. doi:10.1016/0002-9149(75)90027-2. PMID: 1114993. (Closest related work only — does not anchor a tier above IE.)
  • Barron JT, Manrose DL, Liebson PR. Comparison of auscultation with two-dimensional and Doppler echocardiography in patients with suspected mitral valve prolapse. Clin Cardiol. 1988;11(6):401-406. doi:10.1002/clc.4960110608. PMID: 3396240.
  • Barron JT, Manrose DL, Liebson PR. Comparison of auscultation with two-dimensional and Doppler echocardiography in patients with suspected mitral valve prolapse. Clin Cardiol. 1988;11(6):401-406. doi:10.1002/clc.4960110608. PMID: 3396240. (Closest candidate only — does not anchor a tier above IE.)
  • Danford DA, Martin AB, Fletcher SE, Gumbiner CH, Cheatham JP, Hofschire PJ, Kugler JD. Children with heart murmurs: can ventricular septal defect be diagnosed reliably without an echocardiogram? J Am Coll Cardiol. 1997;30(1):243-246. doi:10.1016/s0735-1097(97)00101-0. PMID: 9207649.
  • Skelton R, Evans N, Smythe J. A blinded comparison of clinical and echocardiographic evaluation of the preterm infant for patent ductus arteriosus. J Paediatr Child Health. 1994;30(5):406-411. doi:10.1111/j.1440-1754.1994.tb00689.x. PMID: 7833075.
  • Ohle R, Kareemi HK, Wells G, Perry JJ. Clinical examination for acute aortic dissection: a systematic review and meta-analysis. Acad Emerg Med. 2018;25(4):397-412. doi:10.1111/acem.13360. PMID: 29265487.
  • Stein PD, Beemath A, Matta F, et al. Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II. Am J Med. 2007;120(10):871-879. PMID: 17904458.
  • Hoellerich VL, Wigton RS. Diagnosing pulmonary embolism using clinical findings. Arch Intern Med. 1986;146(9):1699-1704. PMID: 3753109.
  • Goldman L, Caldera DL, Nussbaum SR, et al. Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med. 1977;297(16):845-850. PMID: 904659
  • Ishikawa M, Sakata K, Maki A, Mizuno H, Ishikawa K. Prognostic significance of a clearly audible fourth heart sound detected a month after an acute myocardial infarction. Am J Cardiol. 1997;80(5):619-621. PMID: 9294993.
  • Attenhofer Jost CH, Turina J, Mayer K, et al. Echocardiography in the evaluation of systolic murmurs of unknown cause. Am J Med. 2000;108(8):614-620. PMID: 10856408
  • Aronow WS, Schwartz KS, Koenigsberg M. Correlation of murmurs of mitral stenosis and mitral regurgitation with presence or absence of mitral anular calcium in persons older than 62 years in a long-term health care facility. Am J Cardiol. 1987;59(1):181-182. PMID: 3812240.
  • Bickley LS, Szilagyi PG, Hoffman RM, Soriano RP. Bates' Guide to Physical Examination and History Taking. 13th ed. Philadelphia, PA: Wolters Kluwer; 2021.
  • Swartz MH. Textbook of Physical Diagnosis: History and Examination. 9th ed. Philadelphia, PA: Elsevier; 2025.

Research last updated September 9, 2026.

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