Physical examination maneuver

Physical Exam

Eye Inspection

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Video coming September 2026

How to Perform

Inspect the eyes and surrounding structures. Note the position and alignment of the eyes, the eyelids and lid margins (including any drooping, swelling, or lesions), and the eyelashes. Examine the conjunctiva and sclera for color and injection, the cornea and lens for clarity, and the iris, and note the size, shape, and symmetry of the pupils. Observe for any discharge, excessive tearing, or redness.

How to Interpret

Showing 19 of 35 findings

Anemia

Conjunctival pallor
Rule in
Somewhat helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Limited

Conjunctivitis

Redness observed at 20 feet
Rule in
Minimally helpful
Rule out
Helpful
Evidence:Limited
No discharge
Rule in
Rule out
Somewhat helpful
Evidence:Limited
Purulent discharge
Rule in
Somewhat helpful
Rule out
Evidence:Limited
Matting of both eyes in the morning
Rule in
Somewhat helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Limited
Absence of morning eye matting
Rule in
Not helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Limited
Involvement of both eyes
Rule in
Somewhat helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:Limited
Redness completely obscuring the tarsal vessels
Rule in
Somewhat helpful
Rule out
Not helpful
Evidence:Limited
Follicular conjunctivitis
Rule in
Not helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:Limited
Mucous discharge
Rule in
Not helpful
Rule out
Not helpful
Evidence:Limited
Papillary conjunctivitis
Rule in
InconclusiveWide CI
Rule out
Not helpfulDerived CI
Evidence:Limited
Redness located in the periphery only (no ciliary/circumcorneal flush)
Rule in
Not helpful
Rule out
InconclusiveWide CI
Evidence:Limited
Report of "purulent" secretions
Rule in
Not helpfulWide CI
Rule out
Not helpfulDerived CI
Evidence:Limited
Watery discharge
Rule in
Rule out
InconclusiveWide CI
Evidence:Limited

Hyperthyroidism

Eyelid retraction
Rule in
Very helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Limited

Hypovolemia

Sunken eyes
Rule in
InconclusiveWide CI
Rule out
Somewhat helpful
Evidence:Limited

Orbital Fracture

Periorbital emphysema after facial trauma
Rule in
Somewhat helpful
Rule out
Not helpful
Evidence:Limited

Serious Eye Disease

Anisocoria (≥1 mm difference) with the smaller pupil in the red eye
Rule in
HelpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:Limited

Stroke

Horner syndrome in a patient with acute stroke
Rule in
Not helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:Limited

References

  • Sheth TN, Choudhry NK, Bowes M, Detsky AS. The relation of conjunctival pallor to the presence of anemia. J Gen Intern Med. 1997 Feb;12(2):102-106. doi:10.1046/j.1525-1497.1997.00014.x. PMID: 9051559.
  • Rietveld RP, ter Riet G, Bindels PJE, Sloos JH, van Weert HCPM. Predicting bacterial cause in infectious conjunctivitis: cohort study on informativeness of combinations of signs and symptoms. BMJ. 2004;329(7459):206-210. PMID 15201195.
  • Narayana S, McGee S. Bedside diagnosis of the 'red eye': a systematic review. Am J Med. 2015;128(11):1220-1224.e1. doi:10.1016/j.amjmed.2015.06.026. PMID: 26169885.
  • Rietveld RP, ter Riet G, Bindels PJE, Sloos JH, van Weert HCPM. Predicting bacterial cause in infectious conjunctivitis: cohort study on informativeness of combinations of signs and symptoms. BMJ. 2004;329(7459):206-210. PMID: 15201195. PMC487734 (free full text).
  • Rose GE, Pearson RV. Unequal pupil size in patients with unilateral red eye. BMJ. 1991;302(6776):571-572. PMID: 2021723.
  • McGee S, Abernethy WB 3rd, Simel DL. The rational clinical examination. Is this patient hypovolemic? JAMA. 1999;281(11):1022-1029. PMID: 10086438.
  • Alizadeh AHM, Fatemi SR, Mirzaee V, et al. Clinical features of hepatopulmonary syndrome in cirrhotic patients. World J Gastroenterol. 2006;12(12):1954-1956. PMID: 16610006.
  • Kori SH, Foley KM, Posner JB. Brachial plexus lesions in patients with cancer: 100 cases. Neurology. 1981;31(1):45-50. PMID: 6256684.
  • Nordyke RA, Gilbert FI Jr, Harada ASM. Graves' disease: influence of age on clinical findings. Arch Intern Med. 1988;148(3):626-631. PMID: 3341864. doi:10.1001/archinte.148.3.626.
  • Rozema R, Doff MHJ, Delli K, Spijkervet FKL, van Minnen B. Diagnostic accuracy of physical examination findings for midfacial fractures: a systematic review and meta-analysis. Clin Oral Investig. 2022;26(4):3405-3427. PMID: 35298710.
  • Tao WD, Liu M, Fisher M, et al. Posterior versus anterior circulation infarction: how different are the neurologic deficits? Stroke. 2012;43(8):2060-2065. PMID: 22678088.
  • Comer RM, Dawson E, Plant G, Acheson JF, Lee JP. Causes and outcomes for patients presenting with diplopia to an eye casualty department. Eye (Lond). 2007;21(3):413-418. PMID: 16732215.
  • Narayana S, McGee S. Bedside diagnosis of the 'red eye': a systematic review. Am J Med. 2015;128(11):1220-1224.e1. PMID: 26169885.
  • Subhi Y, Schmidt DC, Al-Bakri M, Bach-Holm D, Kessel L. Diagnostic Test Accuracy of the Red Reflex Test for Ocular Pathology in Infants: A Meta-analysis. JAMA Ophthalmol. 2021;139(1):33-40. PMID: 33180103. PMC7662495 (free full text).
  • Choi RY, Kushner BJ. The accuracy of experienced strabismologists using the Hirschberg and Krimsky tests. Ophthalmology. 1998;105(7):1301-1306. doi:10.1016/S0161-6420(98)97037-3. PMID: 9663237.
  • Bickley LS, Szilagyi PG, Hoffman RM, Soriano RP. Bates' Guide to Physical Examination and History Taking. 13th ed. Philadelphia, PA: Wolters Kluwer; 2021.
  • Swartz MH. Textbook of Physical Diagnosis: History and Examination. 9th ed. Philadelphia, PA: Elsevier; 2025.

Research last updated September 10, 2026.

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