Physical examination maneuver

Physical Exam

Head and Neck Lymph Node Palpation

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How to Perform

With the patient seated and the neck muscles relaxed, use the pads of the fingers and gentle circular pressure to palpate the cervical node groups systematically — preauricular, posterior auricular, occipital, tonsillar, submandibular, submental, the anterior and posterior cervical chains, and the supraclavicular fossae — comparing the two sides. Note the size, consistency, tenderness, and mobility of any node.

How to Interpret

Showing 12 of 24 findings

Conjunctivitis

Preauricular adenopathy
Rule in
Not helpful
Rule out
InconclusiveWide CI
Evidence:Moderate

Infectious Mononucleosis

Posterior auricular adenopathy
Rule in
Very helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Moderate
Posterior cervical lymphadenopathy in an adolescent or young adult
Rule in
Somewhat helpful
Rule out
Minimally helpful
Evidence:Moderate

Malignant Lymphadenopathy

Fixed lymph node, detecting a malignant or granulomatous cause of lymphadenopathy
Rule in
HelpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Moderate
Hard texture, detecting a malignant or granulomatous cause of lymphadenopathy
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Moderate
Generalized lymphadenopathy, detecting a malignant or granulomatous cause
Rule in
Somewhat helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:Moderate
Supraclavicular nodes
Rule in
Somewhat helpfulWide CI
Rule out
Not helpfulDerived CI
Evidence:Moderate
Head and neck nodes (not supraclavicular)
Rule in
Minimally helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Moderate
Lymph node tenderness, detecting a malignant or granulomatous cause of lymphadenopathy
Rule in
Not helpfulWide CI
Rule out
Not helpfulDerived CI
Evidence:Moderate

Thyroid Carcinoma

Cervical (neck) lymphadenopathy in a patient with a goiter / thyroid nodule
Rule in
Somewhat helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:ModerateResearch in progress
Goiter, cervical adenopathy
Rule in
Somewhat helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:ModerateResearch in progress
Thyroid nodule, cervical adenopathy
Rule in
Somewhat helpfulDerived CI
Rule out
Not helpfulDerived CI
Evidence:ModerateResearch in progress

References

Research in progress on one or more findings above; ratings may change.

  • Cai X, Ebell MH, Haines L. Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis. J Am Board Fam Med. 2021 Nov-Dec;34(6):1141-1156. doi:10.3122/jabfm.2021.06.210217. PMID 34772769.
  • Aronson MD, Komaroff AL, Pass TM, Ervin CT, Branch WT. Heterophil antibody in adults with sore throat: frequency and clinical presentation. Ann Intern Med. 1982;96(4):505-508. PMID: 6895981.
  • Shorter ES, Whiteside MM, Harthan JS, et al. Diagnostic accuracy of clinical signs, symptoms and point-of-care testing for early adenoviral conjunctivitis. Clin Exp Optom. 2022;105(7):702-707. PMID: 34751088.
  • Cañete EJ, Sison-Peña CM, Jimeno CA. Clinicopathological, biochemical, and sonographic features of thyroid nodule predictive of malignancy among adult Filipino patients in a tertiary hospital in the Philippines. Endocrinol Metab (Seoul). 2014;29(4):489-497. doi:10.3803/EnM.2014.29.4.489. PMID: 25325270. PMCID: PMC4285043.
  • Narayana S, McGee S. Bedside diagnosis of the 'red eye': a systematic review. Am J Med. 2015;128(11):1220-1224.e1. doi:10.1016/j.amjmed.2015.06.026. PMID: 26169885.
  • Ben-Baruch S, Canaani J, Braunstein R, et al. Predictive parameters for a diagnostic bone marrow biopsy specimen in the work-up of fever of unknown origin. Mayo Clin Proc. 2012;87(2):136-142. PMID: 22226833.
  • Chau I, Kelleher MT, Cunningham D, et al. Rapid access multidisciplinary lymph node diagnostic clinic: analysis of 550 patients. Br J Cancer. 2003;88(3):354-361. PMID: 12569376.
  • Vassilakopoulos TP, Pangalis GA. Application of a prediction rule to select which patients presenting with lymphadenopathy should undergo a lymph node biopsy. Medicine (Baltimore). 2000;79(5):338-347. PMID: 11039082.
  • Garcia-Vives E, Rodriguez-Morera J, Arnau AB, et al. Clinical predictors of malignancy in lymphadenopathy: a multivariable analysis from a quick diagnosis unit. Clin Med (Lond). 2026;26(3):100567. doi:10.1016/j.clinme.2026.100567. PMID: 41850619. PMCID: PMC13096957.
  • Slap GB, Brooks JSJ, Schwartz JS. When to perform biopsies of enlarged peripheral lymph nodes in young patients. JAMA. 1984;252(10):1321-1326. PMID: 6471252.
  • Viacava EP, Pack GT. Significance of supraclavicular signal node in patients with abdominal and thoracic cancer: a study of one hundred and twenty-two cases. Arch Surg. 1944;48:109-119.
  • Ebell MH, Smith MA, Barry HC, Ives K, Carey M. The rational clinical examination. Does this patient have strep throat? JAMA. 2000;284(22):2912-2918. PMID: 11147989.
  • Fijten GH, Blijham GH. Unexplained lymphadenopathy in family practice. An evaluation of the probability of malignant causes and the effectiveness of physicians' workup. J Fam Pract. 1988;27(4):373-376. PMID: 3049914.
  • Bickley LS, Szilagyi PG, Hoffman RM, Soriano RP. Bates' Guide to Physical Examination and History Taking. 13th ed. Philadelphia, PA: Wolters Kluwer; 2021.
  • Swartz MH. Textbook of Physical Diagnosis: History and Examination. 9th ed. Philadelphia, PA: Elsevier; 2025.

Research last updated September 10, 2026.