Physical examination maneuver

Physical Exam

Mental Status Assessment

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Video coming September 2026

How to Perform

Through conversation and targeted tasks, assess the domains of the mental status examination: level of consciousness and arousal; appearance and behavior; attention (for example, digit span); orientation to person, place, and time; memory (immediate, recent, and remote); language (fluency, naming, repetition, comprehension); and higher cognitive functions (calculation, abstraction, and judgment). Standardized instruments may be used to score cognition.

How to Interpret

Showing all 13 findings

Delirium

Confusion Assessment Method (CAM) positive
Rule in
Very helpful
Rule out
Helpful
Evidence:Strong
Confusion Assessment Method for the ICU (CAM-ICU) positive in an ICU patient
Rule in
Very helpful
Rule out
Somewhat helpful
Evidence:Strong
4 'A's Test (4AT) score greater than 3 positive
Rule in
Helpful
Rule out
Helpful
Evidence:Strong
Intensive Care Delirium Screening Checklist (ICDSC) score greater than or equal to 4 positive in an ICU patient
Rule in
Somewhat helpful
Rule out
Somewhat helpful
Evidence:Strong
Single Question in Delirium (SQID) positive
Rule in
Somewhat helpful
Rule out
Minimally helpful
Evidence:Limited

Dementia

Addenbrooke's Cognitive Examination-Revised (ACE-R) total score less than 88 positive
Rule in
Helpful
Rule out
Very helpful
Evidence:Strong
Montreal Cognitive Assessment (MoCA) score less than 26 positive
Rule in
Helpful
Rule out
Very helpful
Evidence:Strong
Mini-Cog score less than or equal to 2 (out of 5) positive in adults 60 or over
Rule in
Helpful
Rule out
Helpful
Evidence:Strong
Mini-Mental State Examination (MMSE) score less than 24 positive in adults 65 or over
Rule in
Helpful
Rule out
Helpful
Evidence:Strong

Major Depressive Disorder

Whooley 2-question screen positive
Rule in
Somewhat helpful
Rule out
Very helpful
Evidence:Strong
Patient Health Questionnaire-9 (PHQ-9) total score greater than or equal to 10 positive
Rule in
Helpful
Rule out
Helpful
Evidence:Strong
Geriatric Depression Scale 15-item short form (GDS-15) total score greater than or equal to 5 positive in older adults
Rule in
Somewhat helpful
Rule out
Helpful
Evidence:Strong
Patient Health Questionnaire-2 (PHQ-2) total score greater than or equal to 3 positive
Rule in
Somewhat helpful
Rule out
Somewhat helpful
Evidence:Strong

References

  • Shi Q, Warren L, Saposnik G, MacDermid JC. Confusion assessment method: a systematic review and meta-analysis of diagnostic accuracy. Neuropsychiatr Dis Treat. 2013;9:1359-1370. doi:10.2147/NDT.S49520. PubMed: 24092976
  • Gusmao-Flores D, Salluh JIF, Chalhub RÁ, Quarantini LC. The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care. 2012;16(4):R115. doi:10.1186/cc11407. PubMed: 22759376
  • Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021;50(3):733-743. doi:10.1093/ageing/afaa224. PubMed: 33951145
  • Sands MB, Sharma S, Carpenter L, Hartshorn A, Lee JT, Lujic S, Congdon ME, Buchanan AM, Agar M, Vardy JL. SQiD, the Single Question in Delirium: can a single question help clinicians to detect delirium in hospitalised cancer patients? BMC Cancer. 2021;21(1):75. PMID: 33461523. doi:10.1186/s12885-020-07504-x. (Prospective multi-center cohort, two comprehensive cancer centres; SQiD informant question vs psychiatrist DSM interview reference standard; n=73 SQiD+psychiatrist subset; sensitivity 0.44, specificity 0.87.) Original validation: Sands MB, Dantoc BP, Hartshorn A, Ryan CJ, Lujic S. Single Question in Delirium (SQiD): testing its efficacy against psychiatrist interview, the Confusion Assessment Method and the Memorial Delirium Assessment Scale. Palliat Med. 2010;24(6):561-565. PMID: 20837733. doi:10.1177/0269216310371556. (Single-center palliative-care cohort, n=21; sensitivity 0.80, specificity 0.71.)
  • Creavin ST, Wisniewski S, Noel-Storr AH, et al. Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database Syst Rev. 2016;(1):CD011145. doi:10.1002/14651858.CD011145.pub2. PubMed: 26760674
  • Wang X, Li F, Gao Q, Jiang Z, Abudusaimaiti X, Yao J, Zhu H. Evaluation of the Accuracy of Cognitive Screening Tests in Detecting Dementia Associated with Alzheimer's Disease: A Hierarchical Bayesian Latent Class Meta-Analysis. J Alzheimers Dis. 2022;87(1):285-304. doi:10.3233/JAD-215394. PubMed: 35275533
  • Tsoi KKF, Chan JYC, Hirai HW, Wong SYS, Kwok TCY. Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis. JAMA Intern Med. 2015;175(9):1450-1458. doi:10.1001/jamainternmed.2015.2152. PubMed: 26052687
  • Levis B, Benedetti A, Thombs BD; DEPRESSD Collaboration. Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ. 2019;365:l1476. doi:10.1136/bmj.l1476. PubMed: 30967483
  • Levis B, Sun Y, He C, et al; DEPRESSD PHQ Collaboration. Accuracy of the PHQ-2 Alone and in Combination With the PHQ-9 for Screening to Detect Major Depression: Individual Participant Data Meta-analysis. JAMA. 2020;323(22):2290-2300. doi:10.1001/jama.2020.6504. PubMed: 32515813
  • Pocklington C, Gilbody S, Manea L, McMillan D. The diagnostic accuracy of brief versions of the Geriatric Depression Scale: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2016;31(8):837-857. doi:10.1002/gps.4407. PubMed: 26890937
  • Bosanquet K, Bailey D, Gilbody S, et al. Diagnostic accuracy of the Whooley questions for the identification of depression: a diagnostic meta-analysis. BMJ Open. 2015;5(12):e008913. doi:10.1136/bmjopen-2015-008913. PubMed: 26656018
  • Bickley LS, Szilagyi PG, Hoffman RM, Soriano RP. Bates' Guide to Physical Examination and History Taking. 13th ed. Philadelphia, PA: Wolters Kluwer; 2021.
  • Swartz MH. Textbook of Physical Diagnosis: History and Examination. 9th ed. Philadelphia, PA: Elsevier; 2025.
  • Talley NJ, O'Connor S. Clinical Examination: A Systematic Guide to Physical Diagnosis. 9th ed. Chatswood, NSW: Elsevier Australia; 2022.