Physical examination maneuver

Physical Exam

Mental Status Assessment

also known as Mental status examination
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How to Perform

Through conversation and targeted tasks, assess the domains of the mental status examination: level of consciousness and arousal; appearance and behavior; attention (for example, spelling "world" backwards); orientation to person, place, and time; memory (immediate, recent, and remote); language (fluency, naming, repetition, comprehension); and higher cognitive functions (calculation, abstraction, and judgment). Standardized instruments may be used to score cognition.

How to Interpret

Showing 22 of 25 findings

Cirrhosis

Encephalopathy
Rule in
Very helpful
Rule out
Not helpful
Evidence:Strong

Delirium

Confusion Assessment Method for the ICU (CAM-ICU) positive in an ICU patient
Rule in
Very helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong
4 "A"s Test (4AT) score greater than 3 positive
Rule in
HelpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Confusion Assessment Method (CAM) positive
Rule in
Helpful
Rule out
Helpful
Evidence:Strong
Disorientation to time, place, or person
Rule in
Somewhat helpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Moderate
Intensive Care Delirium Screening Checklist (ICDSC) score ≥4
Rule in
Somewhat helpfulNo CI
Rule out
Somewhat helpfulNo CI
Evidence:Strong
Single Question in Delirium (SQID) positive
Rule in
Somewhat helpfulWide CI
Rule out
Minimally helpfulDerived CI
Evidence:Moderate

Dementia

Addenbrooke's Cognitive Examination-Revised (ACE-R) total score less than 88 positive
Rule in
Helpful
Rule out
Very helpful
Evidence:Strong
Mini-Cog score less than or equal to 2 (out of 5) positive in adults 60 or over
Rule in
Helpful
Rule out
Very helpful
Evidence:Moderate
Mini-Mental State Examination (MMSE) score less than 24 positive in adults 65 or over
Rule in
HelpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Moderate
Abbreviated Mental Test Score (AMTS/AMT-10, or AMT-4) below threshold
Rule in
Helpful
Rule out
Somewhat helpful
Evidence:Moderate
Montreal Cognitive Assessment (MoCA) score less than 26 positive
Rule in
Somewhat helpful
Rule out
Helpful
Evidence:Strong
Abnormal clock-drawing test
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong
Head-turning sign
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Moderate

Hypovolemia

Confusion
Rule in
InconclusiveWide CI
Rule out
InconclusiveWide CI
Evidence:Moderate

Major Depressive Disorder

Whooley 2-question screen positive
Rule in
Somewhat helpful
Rule out
Very helpful
Evidence:Strong
Patient Health Questionnaire-9 (PHQ-9) score ≥10
Rule in
HelpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Geriatric Depression Scale 15-item short form (GDS-15) score ≥5
Rule in
Somewhat helpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Patient Health Questionnaire-2 (PHQ-2) score ≥3
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong

Stroke

Coma / unresponsiveness on level-of-consciousness assessment
Rule in
Helpful
Rule out
—
Evidence:StrongResearch in progress
Mental status alert
Rule in
—
Rule out
Somewhat helpful
Evidence:StrongResearch in progress
Mental status drowsy
Rule in
InconclusiveWide CI
Rule out
—
Evidence:StrongResearch in progress

References

Research in progress on one or more findings above; ratings may change.

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  • Miranda F, Gonzalez F, Plana MN, Zamora J, Quinn TJ, Seron P. Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings. Cochrane Database Syst Rev. 2023;11(11):CD013126. doi:10.1002/14651858.CD013126.pub2. PMID: 37987526. PMCID: PMC10661047.
  • Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021;50(3):733-743. doi:10.1093/ageing/afaa224. PubMed: 33951145
  • Gusmao-Flores D, Salluh JIF, Chalhub RÁ, Quarantini LC. The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care. 2012;16(4):R115. doi:10.1186/cc11407. PubMed: 22759376
  • Sands MB, Sharma S, Carpenter L, Hartshorn A, Lee JT, Lujic S, Congdon ME, Buchanan AM, Agar M, Vardy JL. SQiD, the Single Question in Delirium: can a single question help clinicians to detect delirium in hospitalised cancer patients? BMC Cancer. 2021;21(1):75. PMID: 33461523. doi:10.1186/s12885-020-07504-x. Original validation: Sands MB, Dantoc BP, Hartshorn A, Ryan CJ, Lujic S. Single Question in Delirium (SQiD): testing its efficacy against psychiatrist interview, the Confusion Assessment Method and the Memorial Delirium Assessment Scale. Palliat Med. 2010;24(6):561-565. PMID: 20837733. doi:10.1177/0269216310371556.
  • Hogan P, Cheston H, Dunne O, Gardner D, McWhirter A, Rawle MJ, Stoodley I, Richardson SJ, Allan LM, MacLullich AMJ, Davis DHJ, Tsui A. Diagnostic test accuracies of 4AT items are consistent across the range of baseline cognition: results from two prospective studies. Age Ageing. 2026;55(6):afag182. doi:10.1093/ageing/afag182. PMID: 42341202. PMCID: PMC13293242.
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  • Park J, Jeong E, Seomun G. The clock drawing test: A systematic review and meta-analysis of diagnostic accuracy. J Adv Nurs. 2018;74(12):2742-2754. PMID: 30047147.
  • Jackson TA, Naqvi SH, Sheehan B. Screening for dementia in general hospital inpatients: a systematic review and meta-analysis of available instruments. Age Ageing. 2013;42(6):689-695. doi:10.1093/ageing/aft145. PMID: 24100618.
  • Soysal P, Usarel C, Ispirli G, Isik AT. Attended With and Head-Turning Sign can be clinical markers of cognitive impairment in older adults. Int Psychogeriatr. 2017;29(11):1763-1769. PMID: 28660847.
  • Levis B, Benedetti A, Thombs BD; DEPRESSD Collaboration. Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ. 2019;365:l1476. doi:10.1136/bmj.l1476. PubMed: 30967483
  • Levis B, Sun Y, He C, Wu Y, Krishnan A, Bhandari PM, Neupane D, Imran M, Brehaut E, Negeri Z, Fischer FH, Benedetti A, Thombs BD; Depression Screening Data (DEPRESSD) PHQ Collaboration. Accuracy of the PHQ-2 Alone and in Combination With the PHQ-9 for Screening to Detect Major Depression: Systematic Review and Meta-analysis. JAMA. 2020;323(22):2290-2300. doi:10.1001/jama.2020.6504. PMID: 32515813.
  • Pocklington C, Gilbody S, Manea L, McMillan D. The diagnostic accuracy of brief versions of the Geriatric Depression Scale: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2016;31(8):837-857. doi:10.1002/gps.4407. PubMed: 26890937
  • Bosanquet K, Bailey D, Gilbody S, et al. Diagnostic accuracy of the Whooley questions for the identification of depression: a diagnostic meta-analysis. BMJ Open. 2015;5(12):e008913. doi:10.1136/bmjopen-2015-008913. PubMed: 26656018
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  • Jaimes F, Arango C, Ruiz G, et al. Predicting bacteremia at the bedside. Clin Infect Dis. 2004;38(3):357-362. PMID: 14727205.
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  • Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;303(22):2280-2286. doi:10.1001/jama.2010.754. PMID: 20530782.
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  • Bickley LS, Szilagyi PG, Hoffman RM, Soriano RP. Bates' Guide to Physical Examination and History Taking. 13th ed. Philadelphia, PA: Wolters Kluwer; 2021.
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Research last updated September 10, 2026.