Physical examination maneuver

Physical Exam

Mental Status Assessment

also known as Mental status examination
🎬
Video coming September 2026

How to Perform

Through conversation and targeted tasks, assess the domains of the mental status examination: level of consciousness and arousal; appearance and behavior; attention (for example, spelling "world" backwards); orientation to person, place, and time; memory (immediate, recent, and remote); language (fluency, naming, repetition, comprehension); and higher cognitive functions (calculation, abstraction, and judgment). Standardized instruments may be used to score cognition.

How to Interpret

Showing 22 of 25 findings

Cirrhosis

Encephalopathy
Rule in
Very helpful
Rule out
Not helpful
Evidence:Strong

Delirium

Confusion Assessment Method for the ICU (CAM-ICU) positive in an ICU patient
Rule in
Very helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong
4 "A"s Test (4AT) score greater than 3 positive
Rule in
HelpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Confusion Assessment Method (CAM) positive
Rule in
Helpful
Rule out
Helpful
Evidence:Strong
Disorientation to time, place, or person
Rule in
Somewhat helpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Limited
Intensive Care Delirium Screening Checklist (ICDSC) score ≥4
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong
Single Question in Delirium (SQID) positive
Rule in
Somewhat helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Limited

Dementia

Addenbrooke's Cognitive Examination-Revised (ACE-R) total score less than 88 positive
Rule in
HelpfulDerived CI
Rule out
Very helpfulDerived CI
Evidence:Strong
Mini-Cog score less than or equal to 2 (out of 5) positive in adults 60 or over
Rule in
HelpfulDerived CI
Rule out
Very helpfulDerived CI
Evidence:Limited
Mini-Mental State Examination (MMSE) score less than 24 positive in adults 65 or over
Rule in
HelpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Limited
Abbreviated Mental Test Score (AMTS/AMT-10, or AMT-4) below threshold
Rule in
HelpfulNo CI
Rule out
Somewhat helpfulNo CI
Evidence:LimitedResearch in progress
Montreal Cognitive Assessment (MoCA) score less than 26 positive
Rule in
Somewhat helpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Abnormal clock-drawing test
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong
Head-turning sign
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Limited

Hypovolemia

Confusion
Rule in
InconclusiveWide CI
Rule out
InconclusiveWide CI
Evidence:Limited

Major Depressive Disorder

Whooley 2-question screen positive
Rule in
Somewhat helpfulDerived CI
Rule out
Very helpfulDerived CI
Evidence:Strong
Patient Health Questionnaire-9 (PHQ-9) score ≥10
Rule in
HelpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Geriatric Depression Scale 15-item short form (GDS-15) score ≥5
Rule in
Somewhat helpfulDerived CI
Rule out
HelpfulDerived CI
Evidence:Strong
Patient Health Questionnaire-2 (PHQ-2) score ≥3
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Strong

Stroke

Coma / unresponsiveness on level-of-consciousness assessment
Rule in
Helpful
Rule out
Evidence:Strong
Mental status alert
Rule in
Rule out
Somewhat helpful
Evidence:Strong
Mental status drowsy
Rule in
InconclusiveWide CI
Rule out
Evidence:Strong

References

Research in progress on one or more findings above; ratings may change.

  • Shi Q, Warren L, Saposnik G, MacDermid JC. Confusion assessment method: a systematic review and meta-analysis of diagnostic accuracy. Neuropsychiatr Dis Treat. 2013;9:1359-1370. doi:10.2147/NDT.S49520. PubMed: 24092976
  • Gusmao-Flores D, Salluh JIF, Chalhub RÁ, Quarantini LC. The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care. 2012;16(4):R115. doi:10.1186/cc11407. PubMed: 22759376
  • Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021;50(3):733-743. doi:10.1093/ageing/afaa224. PubMed: 33951145
  • Sands MB, Sharma S, Carpenter L, Hartshorn A, Lee JT, Lujic S, Congdon ME, Buchanan AM, Agar M, Vardy JL. SQiD, the Single Question in Delirium: can a single question help clinicians to detect delirium in hospitalised cancer patients? BMC Cancer. 2021;21(1):75. PMID: 33461523. doi:10.1186/s12885-020-07504-x. Original validation: Sands MB, Dantoc BP, Hartshorn A, Ryan CJ, Lujic S. Single Question in Delirium (SQiD): testing its efficacy against psychiatrist interview, the Confusion Assessment Method and the Memorial Delirium Assessment Scale. Palliat Med. 2010;24(6):561-565. PMID: 20837733. doi:10.1177/0269216310371556.
  • O'Keeffe E, Mukhtar O, O'Keeffe ST. Orientation to time as a guide to the presence and severity of cognitive impairment in older hospital patients. J Neurol Neurosurg Psychiatry. 2011;82(5):500-504. PMID: 20852313.
  • Creavin ST, Wisniewski S, Noel-Storr AH, et al. Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database Syst Rev. 2016;(1):CD011145. doi:10.1002/14651858.CD011145.pub2. PubMed: 26760674
  • Tsoi KKF, Chan JYC, Hirai HW, Wong SYS, Kwok TCY. Cognitive tests to detect dementia: a systematic review and meta-analysis. JAMA Intern Med. 2015;175(9):1450-1458. doi:10.1001/jamainternmed.2015.2152. PMID: 26052687.
  • Park J, Jeong E, Seomun G. The clock drawing test: A systematic review and meta-analysis of diagnostic accuracy. J Adv Nurs. 2018;74(12):2742-2754. PMID: 30047147.
  • Jackson TA, Naqvi SH, Sheehan B. Screening for dementia in general hospital inpatients: a systematic review and meta-analysis of available instruments. Age Ageing. 2013;42(6):689-695. doi:10.1093/ageing/aft145. PMID: 24100618.
  • Soysal P, Usarel C, Ispirli G, Isik AT. Attended With and Head-Turning Sign can be clinical markers of cognitive impairment in older adults. Int Psychogeriatr. 2017;29(11):1763-1769. PMID: 28660847.
  • Levis B, Benedetti A, Thombs BD; DEPRESSD Collaboration. Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ. 2019;365:l1476. doi:10.1136/bmj.l1476. PubMed: 30967483
  • Levis B, Sun Y, He C, Wu Y, Krishnan A, Bhandari PM, Neupane D, Imran M, Brehaut E, Negeri Z, Fischer FH, Benedetti A, Thombs BD; Depression Screening Data (DEPRESSD) PHQ Collaboration. Accuracy of the PHQ-2 Alone and in Combination With the PHQ-9 for Screening to Detect Major Depression: Systematic Review and Meta-analysis. JAMA. 2020;323(22):2290-2300. doi:10.1001/jama.2020.6504. PMID: 32515813.
  • Pocklington C, Gilbody S, Manea L, McMillan D. The diagnostic accuracy of brief versions of the Geriatric Depression Scale: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2016;31(8):837-857. doi:10.1002/gps.4407. PubMed: 26890937
  • Bosanquet K, Bailey D, Gilbody S, et al. Diagnostic accuracy of the Whooley questions for the identification of depression: a diagnostic meta-analysis. BMJ Open. 2015;5(12):e008913. doi:10.1136/bmjopen-2015-008913. PubMed: 26656018
  • Udell JA, Wang CS, Tinmouth J, FitzGerald JM, Ayas NT, Simel DL, Schulzer M, Mak E, Yoshida EM. Does this patient with liver disease have cirrhosis? JAMA. 2012;307(8):832-842. PMID: 22357834.
  • Jaimes F, Arango C, Ruiz G, et al. Predicting bacteremia at the bedside. Clin Infect Dis. 2004;38(3):357-362. PMID: 14727205.
  • Fine MJ, Smith MA, Carson CA, et al. Prognosis and outcomes of patients with community-acquired pneumonia: a meta-analysis. JAMA. 1996;275(2):134-141. PMID: 8531309.
  • McGee S, Abernethy WB 3rd, Simel DL. The rational clinical examination. Is this patient hypovolemic? JAMA. 1999;281(11):1022-1029. PMID: 10086438.
  • Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;303(22):2280-2286. doi:10.1001/jama.2010.754. PMID: 20530782.
  • Mehr DR, Binder EF, Kruse RL, Zweig SC, Madsen RW, D'Agostino RB. Clinical findings associated with radiographic pneumonia in nursing home residents. J Fam Pract. 2001;50(11):931-937. PMID: 11711008.
  • Bickley LS, Szilagyi PG, Hoffman RM, Soriano RP. Bates' Guide to Physical Examination and History Taking. 13th ed. Philadelphia, PA: Wolters Kluwer; 2021.
  • Swartz MH. Textbook of Physical Diagnosis: History and Examination. 9th ed. Philadelphia, PA: Elsevier; 2025.
  • Talley NJ, O'Connor S. Clinical Examination: A Systematic Guide to Physical Diagnosis. 9th ed. Chatswood, NSW: Elsevier Australia; 2022.

Research last updated September 10, 2026.