Physical examination maneuver

Physical Exam

Spleen Palpation

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How to Perform

With the patient supine, stand at the right side and reach across with your left hand to support and gently lift the lower left rib cage from behind. Place your right hand flat on the abdomen, beginning in the right lower quadrant. Press gently inward and upward as the patient takes a deep breath, feeling for the splenic edge to descend against your fingers. If no edge is felt, move your right hand diagonally toward the left upper quadrant in small increments, repeating the maneuver with each inspiration until you reach the left costal margin.

How to Interpret

Showing 7 of 17 findings

Cirrhosis

Palpable spleen tip
Rule in
Somewhat helpful
Rule out
Not helpful
Evidence:Strong

Hepatocellular Jaundice

Palpable spleen in a jaundiced patient, detecting hepatocellular rather than obstructive disease
Rule in
InconclusiveWide CI
Rule out
Not helpfulDerived CI
Evidence:Moderate

Infectious Mononucleosis

Palpable spleen tip in an adolescent or young adult
Rule in
Somewhat helpfulWide CI
Rule out
Minimally helpful
Evidence:Strong

Infective Endocarditis

Palpable spleen tip
Rule in
Somewhat helpfulNo CI
Rule out
Not helpfulNo CI
Evidence:Moderate

Malaria

Palpable spleen in returning travelers with fever
Rule in
Helpful
Rule out
Not helpful
Evidence:Strong

Myelofibrosis

Massive splenomegaly (extending past midline or to pelvis)
Rule in
Somewhat helpfulDerived CI
Rule out
Somewhat helpfulDerived CI
Evidence:Moderate

Splenomegaly

Palpable spleen tip
Rule in
Very helpfulDerived CI
Rule out
Minimally helpfulDerived CI
Evidence:Moderate

References

Research in progress on one or more findings above; ratings may change.

  • Dubey S, Swaroop A, Jain R, Verma K, Garg P, Agarwal S. Percussion of Traube's space--a useful index of splenic enlargement. J Assoc Physicians India. 2000;48(3):326-328. PMID: 11229121.
  • Cai X, Ebell MH, Haines L. Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis. J Am Board Fam Med. 2021 Nov-Dec;34(6):1141-1156. doi:10.3122/jabfm.2021.06.210217. PMID 34772769.
  • Ben-Baruch S, Canaani J, Braunstein R, et al. Predictive parameters for a diagnostic bone marrow biopsy specimen in the work-up of fever of unknown origin. Mayo Clin Proc. 2012;87(2):136-142. PMID: 22226833.
  • Richet H, Casalta JP, Thuny F, Mérrien J, Harlé JR, Weiller PJ, Habib G, Raoult D. Development and assessment of a new early scoring system using non-specific clinical signs and biological results to identify children and adult patients with a high probability of infective endocarditis on admission. J Antimicrob Chemother. 2008;62(6):1434-1440. doi:10.1093/jac/dkn423. PMID: 18952617. PMCID: PMC2583066.
  • O'Reilly RA. Splenomegaly in 2,505 patients at a large university medical center from 1913 to 1995. 1913 to 1962: 2,056 patients. West J Med. 1998;169(2):78-87. PMID: 9735688. PMCID: PMC1305176.
  • Udell JA, Wang CS, Tinmouth J, FitzGerald JM, Ayas NT, Simel DL, Schulzer M, Mak E, Yoshida EM. Does this patient with liver disease have cirrhosis? JAMA. 2012;307(8):832-842. doi:10.1001/jama.2012.186. PMID: 22357834.
  • Lucijanic M, Krecak I, Soric E, et al. Palpable spleen size is differently prognostic in primary and secondary myelofibrosis. Leuk Lymphoma. 2023;64(4):893-896. PMID: 36799562.
  • Taylor SM, Molyneux ME, Simel DL, Meshnick SR, Juliano JJ. Does this patient have malaria? JAMA. 2010;304(18):2048-2056. PMID: 21057136.
  • Schenker S, Balint J, Schiff L. Differential diagnosis of jaundice: report of a prospective study of 61 proved cases. Am J Dig Dis. 1962;7(5):449-463. PMID: 13991584.
  • Williamson HA Jr. Lymphadenopathy in a family practice: a descriptive study of 249 cases. J Fam Pract. 1985;20(5):449-452. PMID: 3989485. Corroborating closest candidate: Vassilakopoulos TP, Pangalis GA. Medicine (Baltimore). 2000;79(5):338-347. PMID: 11039082.
  • McGee S. Evidence-Based Physical Diagnosis. 6th ed. Philadelphia, PA: Elsevier; 2025.

Research last updated September 10, 2026.